The aim of this paper is to investigate the ability of various herbal extracts and pure compounds which come as constituents of these extracts in the inhibition of two enzymes important in the pathogenesis of Alzheimer's disease; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The subject of the study were phenolic compounds, primarily flavonoids. To this end, scientific databases (ScienceDirect, Web of Science, PubMed, Google Scholar, PMC and PubChem). AChE and BChE play an important role in the hydrolysis of acetylcholine resulting in nerve impulse transmission. AChE and BChE inhibitors are used as medicines, but because of the side effects, scientists are looking for new inhibitors, isolated from plants. The results showed that 6-OH-luteolin-7-O-β-D-glucoside, pomiferin, (2S)-5,2-dihydroxy-7,5-dimethoxyflavanone, hispidone, 3-methoxyquercetin and tiliroside have significant inhibitory activity on AChE. Furthermore, of all plant extracts, Moringa oleifera root extracts (ethanol and methanol) and Carpolobia lutea root extracts (ethyl acetate, aqueous and methanol) achieved the best results in AChE inhibition.