Paginacija
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Evaluation of in silico databases for the classification of genomic alterations in oncological samples
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Veronique Agnes Amann Objectives: The aim of the first (major) part of this study was to identify and evaluate the most important in silico databases, that are commonly used by VarSome, regarding basic principles of function, classification output (scores and thresholds), web link and PMID number. The second (minor) aim of this study was to investigate in a pilot study, how well the classifications of yet unidentified genomic alterations in oncological samples, predicted by in silico databases, are congruent with...
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Evaluation of stress response in patients following cardiac surgery
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Lara Sophia Vötgen Objectives: The aim of the current study was to investigate the magnitude of stress response in patients undergoing cardiac surgery, with an additional focus on the possible variations of stress response between cardiac surgery with and without CPB.
Patients and methods: This study enrolled 125 patients, aged between 41 and 84 years, who were scheduled for elective CABG, heart valve surgery or combined surgery, with or without CPB. Excluded from the study were patients with mental...
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Evaluation of the frequency and necessity of proton-pump-inhibitor therapy in geriatric patients
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Anna Laura Emma Müller Objectives: The aim of this study was to investigate the usage of proton pump inhibitors in geriatric patients in the general medicine ward. Additionally, the study also looked into polypharmacy among those patients.
Materials and Methods: This retrospective study analyzed medical histories and medication lists of patients in the general medicine ward at Regiomed Klinikum Coburg during June 2019 and June 2023. A convenience sample of 154 geriatric patients was used during the selection...
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Evaluation of the “Uroli App” for Urinary Stone Metaphylaxis
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Katharina Sklorz Objectives: The aim of our study was to analyze, how effective the “Uroli” application is to support the metaphylaxis of adult patients with urolithiasis after acute treatment of a kidney or ureter stone, compared to metaphylaxis without the “Uroli” application in terms of medical benefit and patient-relevant structural and procedural improvements. Fluid intake, urine pH values and specific gravity were examined in the respective groups.
Materials and Methods: This prospective RCT...
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Evocirani potencijal P300 u bolesnika s blagim spoznajnim oštećenjem
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Stipe Medvidović CILJ ISTRAŽIVANJA:
Prikazati razlike amplitude i latencije vala P300 između ispitanika s blagim spoznajnim
oštećenjem i ispitanika iz kontrolne skupine.
USTROJ ISTRAŽIVANJA:
Provedena je presječna studija u trajanju od 1. travnja 2012. god. do 10. srpnja 2012. god.
Glavni kriterij uključivanja bila je dijagnoza blagog spoznajnog oštećenja.
MJESTO ISTRAŽIVANJA:
Istraživanje je provedeno na Klinici za neurologiju KBC-a Split, referentni centar za evocirane
potencijale...
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Explorative study about the effect of classical music on procedure related anxiety in patients with peripheral artery disease
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Johannes Pampel Objectives: The aim of this study was to evaluate a newly assembled classical music playlist
with a qualitative survey as well as its effect on procedure related anxiety measured with mNRS
and physiologic parameters in patients with peripheral artery disease (PAD). Therefore, patients
receiving percutaneous transluminal angioplasty (PTA) where randomly assigned to a music
and control group. In addition, anamnestic and demographic data was analyzed.
Subjects and methods: 25 patients were...
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Expression of hypoxia-inducible factor-1 alpha (HIF-1α) in high grade and low grade endometrial carcinomas
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Leon Romeo Schmid Objectives: to investigate HIF-1α immunohistochemical expression in high grade and low grade endometrial carcinomas and to compared the results. Patient’s age at the time of diagnosis, tumor size, depth of myometrial invasion, presence of vascular invasion and lymph node involvement was also noted for each studied group and compared.
Subject and method: 10 cases of high grade endometrial carcinoma and 10 cases of low grade endometrial carcinoma were enrolled in the study....
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Expression of inversin and DVL-1 in the liver of yotari (Dab1-/-) and wild-type mice
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Vanessa Elena Preid Galešić Objectives: Invs and DVL-1 expression patterns in the liver of yot (Dab1-/-) mice are
the focus of this study, which attempts to clarify their possible roles in the pathophysiology of
hepatic abnormalities linked to the Dab1 loss. This study aims to advance knowledge of the
molecular processes that underlie the emergence of hepatic dysfunction in the context of Dab1
disruption, elucidating possible ramifications for hepatic physiology and associated treatment
approaches.
Materials and...
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Expression of vitamin D receptors in the superior cervical ganglia of rats
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Genia Marlen Gordana Kretzschmar Objectives: We investigated the distribution of vitamin D receptors (VDR), 1α-hydroxylase (1-α- OHase/ CYP27B1), 24-hydroxylase (CYP24) in neuronal subpopulations and satellite glia in the superior cervical ganglia (SCGs) of rats.
Materials and methods: Four male Sprague-Dawley rats were raised under controlled conditions. The rats were sacrificed at twelwe weeks of age, and their superior cervical ganglia embedded in paraffin and prepared for immunohistochemistry. The intensity of...
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Expression pattern of Snail in the kidneys of streptozotocin-induced diabetic rats
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Samy Mehdi Ksouri Objectives: The most prevalent cause of chronic kidney disease is diabetic nephropathy (DN), which can lead to end-stage renal disease (ESRD) and premature death in developed countries but knowledge about these changes is still unsatisfactorily. Specific factors can be used to study developmental pathways and changes in rat diabetic kidneys. Snail is a superfamily of genes that has been found to control gastrulation and neural crest EMT through E-cadherin down-regulation. Snail is located in...
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Expression pattern of Syndecan-1 and HSP-70 in hip tissue of patients with osteoarthritis
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Julian Kaufman Objectives: The purpose of this study is to investigate the expression of Syndecan-1 and HSP-70 in synovial, chondral and subchondral tissue in the hip of human patients with osteoarthritis according to their disease severity.
Materials and methods: Total hip arthroplasty with tissue extraction from the weightbearing area of the pathologic femoral head was performed on all patients. Patients were divided into two groups according to their disease severity defined by their Kellgran Lawrence,...
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