Introduction: Renal cell carcinoma (RCC) is the most common type of kidney cancer with a continuous increase in incidence and mortality in the world. Therefore, the efforts of numerous research groups are focused on the detection of significant diagnostic, prognostic and therapeutic markers that would improve the quality of health care for patients with renal cell carcinoma. Objectives: The aims of our study were to determine the expression of VEGF, FGFR1 and FGFR2 markers in different stages of renal cell carcinoma in regard to the expression in normal tissue and to determine the colocalization of VEGF with FGFR1 and FGFR2 in renal cell carcinoma considering the pathohistological tumor grade. Materials and methods: The study was performed on samples of tumor tissue and normal renal tissue, taken from respondents diagnosed with low (5 samples) and high grade (5 samples) renal cell carcinoma according to the WHO. Double imunofluorescence staining of renal cell carcinoma tissue sections was performed and controlled on combination of VEGF with FGFR1 and FGFR2. The percentage of positive cells was calculated on ten representative fields from each section and expressed as mean ± SD and in the relationship between the groups (low and high stage and control group). We used the Kruskal-Wallis and Dunn posthoc test for data analysis. Results: The results of our study showed a positive immunohistochemical expression of VEGF, FGFR1 and FGFR2 in low and high grade renal cell carcinoma tissue, as well as in normal renal tissue. Occasional colocalization of FGFR1 and VEGF in normal renal tissue and colocalization of FGFR1 and FGFR2 with VEGF in low and high grade renal carcinoma, was established. In normal renal tissue, FGFR1, FGFR2 and VEGF showed mild reactivity. In low grade renal cell carcinoma tissue, FGFR1 showed moderate reactivity, while FGFR2 and VEGF showed mild reactivity. In high grade renal cell carcinoma tissue, all markers showed moderate reactivity. The colocalization of VEGF with FGFR1 and FGFR2 in low and high grade renal carcinoma, was determined. Conclusion: Based on the results, the expression and colocalization of VEGF, FGFR1 and FGFR2 markers in different stages of renal cell carcinoma and in normal renal tissue, were determined. These results contribute to a better understanding of the role of these factors in different pathohistological stages of renal cell carcinoma.