Objective: The main objective of this study was to determine the attitudes and knowledge of dental students from Ljubljana, Rijeka, Split, Sarajevo and Zagreb on dental care for cardiovascular patients and whether there is a need to introduce additional education on this topic during dental studies. Materials and methods: A total of 103 subjects participated in this study. The research was conducted among students in the 5th and 6th year of dental medicine in Ljubljana, Rijeka, Split, Sarajevo and Zagreb. The research was conducted by sending anonymous online questionnaires consisting of 31 specific questions. After the answers were obtained, a statistical analysis of the data was performed. Results: Students studied in several different courses on dental care for cardiovascular patients, but only 22% of students think they have enough knowledge to provide dental care to cardiovascular patients, and 60% of them rarely had the opportunity to work with such patients. 67% of students think that there is not enough agreed literature on this topic. 93% of students are aware of the high incidence of cardiovascular diseases and their serious consequences. For 11 claims, a statistically significant difference in knowledge was demonstrated between faculties using the Kruskal-Wallis ANOVA test and the multiple comparison test. The best knowledge is shown in the claims about the prophylaxis of infective endocarditis, among other things in the statement: “Antibiotic prophylaxis is needed in people who have had infectious endocarditis (IE)“, all students except the Sarajevo Faculty answered correctly and 91.7% of Sarajevo students answered the statement correctly. As for the claim, "Clindamycin is given prophylactically at a dose of 600 mg, one hour before the dental procedure." the percentage of correct answers was 83%. The biggest differences in knowledge between faculties related to claims about drug interactions. To the claim "Miconazole (an antifungal) causes an undesirable reaction with warfarin by increasing its activity." 0% of students from Ljubljana answered correctly, while only 16.7% of students from Sarajevo agreed with the statement. Rijeka and Split had a high percentage of correct answers. The low percentage of correct answers in all faculties is also characteristic of the statement "The use of adrenaline-impregnated retraction suture for the gingiva can cause changes in blood pressure." To this statement, only 47% of students answered that they agree or that they completely agree. Conclusion: Despite the fact that most of the students received some education about cardiovascular diseases and possible interactions and side effects, except for a few questions, students generally showed a below-average level of knowledge in all five faculties. According to the results of the research, additional education and more clinical practice during the studies are needed.