Study Design. Spine deformity and pain-related behavior following laminectomy with and without spine stabilization were investigated. Objectives. We tested hypothesis that spine stabilization following extensive laminectomy can prevent spine deformation and consequent pain-related behavior. Summary of Background Data. Various ablative procedures requiring laminectomy have been tested for prevention or reversal of pain-related behavior in studies using experimental animals. However there is no precise description indicating how laminectomy should be performed. Lack of standardized surgical techniques makes it difficult to achieve uniformity of result reporting and meaningfully compare results of different research groups. Methods. To test or hypothesis, extensive laminectomy with and without spine stabilization was performed in Sprague-Dawley rats. For stabilization of the spine U-shaped surgical wire was used. To test the development of neuropathic pain behavior after surgery, a validated test of mechanical hyperalgesia was used. Deformity of the spine was evaluated by calculating deviation from the central axis on radiographs taken in anterioposterior projection. Results. Surgical stabilization of the spine after laminectomy prevented development of spinal deformity. Laminectomy without stabilization induced hyperalgesia on the 8th and 15th day after surgery. Group with stabilized spine exhibited significant reduction in pain-related behavior on the 8th and 15th postoperative day, compared with the group without stabilization. Conclusion. Surgical stabilization of the spine following laminectomy prevented development of spinal deformity and pain-related behavior. Our results suggest that spine stabilization procedure should be used in all experimental pain models where laminectomy is performed.