Završni radovi | Repozitorij MEFST

: Regulatorni zahtjevi za probiotike; Marina Kojundžić
Cilj istraživanja: Cilj ovog istraživanja je istražiti regulatorni okvir za probiotike na globalnoj razini. Materijal i metode: Napravljen je pregled postojeće regulacije probiotičkih proizvoda u SAD-u, Kanadi, Japanu, Australiji i Novom Zelandu i EU. Shodno tome, analizirani su pravni propisi i zakonski tekstovi koji se tiču kategorija u koje spadaju probiotički proizvodi. Također su pregledane publikacije i smjernice regulatornih agencija pojednih država. Rezultati su prikazani...

: Reguliranje proizvoda medicinske konoplje; Lara Ramić
Cilj: Cilj ovog istraživanja je istražiti regulatorni okvir medicinske konoplje na globalnoj razini. Materijal i metode: Napravljen je pregled postojeće regulacije proizvoda medicinske konoplje u EU, SAD-u, Kanadi, Japanu, Australiji i Novom Zelandu. Analizirani su pravni propisi i zakonski tekstovi koji definiraju status medicinske konoplje u pojedinoj državi. Fokus pretraživanja regulative medicinskog kanabisa bio je na lijekovima s odobrenjem za stavljanje u promet, načinu...

: Relationship between cardiac contractile performance and mitochondrial respiratory capacity in patients undergoing coronary artery bypass grafting surgery; Andreas Wolk
Objectives: The purpose of this study was to investigate a relationship between cardiac contractile performance and mitochondrial respiratory capacity in myocardium of patients who underwent coronary artery bypass (CABG) surgery. Materials and methods: The study included forty-one (thirty-two men and nine women) hemodynamically stable patients with coronary artery disease undergoing CABG surgery. Emergency patients, patients with ejection fraction (EF) below 40%, patients with...

: Reporting of adverse events of COVID-19 vaccines and drugs to the Food and Drug Administration Adverse Event Reporting System and EudraVigilance During the COVID-19 pandemic; Yannick Krautwurst
Objectives: The aims of this study were to determine whether there are differences in the frequency of adverse events (AEs) from COVID-19 vaccines compared to widely issued vaccines and from COVID-19 drugs in contrast to a widely prescribed drug reported to the FDA Adverse Event Reporting System (FAERS) or EudraVigilance (EV) during the COVID- 19 pandemic. Materials and methods: The FAERS and EV adverse event databases were searched for adverse event reports filed in the U.S. and...

: Reporting of sex and race/ethnicity in randomized controlled trials of interventions published in the top journals from the field of anesthesiology and pain; Clemens Jan Janda-Martinac
Aim: The aim of this study was to assess reporting of data on sex and race/ethnicity in randomized controlled trials (RCTs) of interventions published in the highest-ranking journals from the field of anesthesiology. Methods: We analyzed RCTs published from 2014 to mid-2017 in the seven journals belonging to the top 25% in the field of Anesthesiology according to the 2016 Journal Impact Factor published by the database Journal Citation Reports. We extracted data regarding terminology for...

: Reproduktivno zdravlje i planiranje obitelji u svezi s demografskim promjenama u Republici Hrvatskoj; Tomislava Ćerluka
Cilj: Prikazati trenutno stanje u Republici Hrvatskoj u svezi s reproduktivnim zdravljem i planiranjem obitelji te naglasiti važnost javnozdravstvenog problema demografskog starenja i reproduktivnog zdravlja u našoj sredini. Povezati postojeće objavljene rezultate za Republiku Hrvatsku u odnosu na stavove studenata Sveučilišta u Splitu. Posebnu pažnju usmjeriti prema različitim stavovima po spolu i razlikama u stavu u svezi sa znanjem o predmetu istraživanja. Materijal i metode:...

: Retrospective analysis of disease severity and symptoms across the SARS-CoV-2 variants; Johanna Huntemann
Objectives: The aim of our study was to investigate if there is a difference in the presence of symptoms in different phases of COVID-19. Additionally, we explored potential differences in SARS-CoV- 2 variants regarding their disease severity. Material and Methods: The study was designed as a retrospective cohort study, conducted at the REGIOMED Hospital in Coburg, Bavaria, Germany. Patients that had a positive SARS-CoV-2 PCR-test result and were hospitalized at the REGIOMED hospital in...

: Retrospective analysis of hospitalized patients, comparing different SARS-CoV-2 variants regarding anosmia; Silvio Heinig
Objectives: The objective of this cross-sectional survey study was to investigate the prevalence, severity, and duration of post-COVID symptoms, with a specific focus on olfactory dysfunction. The study aimed to compare different virus variants of concern and explore potential associations between modifiable and non-modifiable risk factors and the prevalence or severity of symptoms. Materials and Methods: The study involved former hospitalized patients at Coburg REGIOMED...

: Retrospective analysis of post-COVID-19 symptoms in hospitalized patients, comparing the different SARS-COV-2-variants regarding headache; Tim Frederik Lemcke
Objectives: The objective of this study was to collect new data on the post-COVID period, with a specific focus on headaches, including their symptom prevalence, duration, and influencing factors, while comparing different virus variants. the analysis aimed to explore potential associations between its variables, particularly paying attention to smoking/alcohol consumption, gender, age, preexisting headache, immune status, and other Long-COVID symptoms. The study was conducted...

: Retrospective analysis of stereotactic radiotherapy for primary intrapulmonary lesions; Justus Valentini
Objectives: The objective of this retrospective study was to evaluate the outcomes of patients with early-stage lung cancer that were treated by stereotactic radiotherapy. Endpoints included overall survival, local control, local progression-free survival and their possible prognostic factors as well as quality of life data. Materials and methods: Between 2014 and 2021, a total of 51 patients meeting the inclusion criteria were evaluated. All patients have been treated by...

: Retrospective analysis of survival data in patients with non-small cell lung cancer (NSCLC) following radiation and chemotherapy : The impact of mutations of the epidermal growth factor receptor (EGFR); Katharina Endres
Objectives: The goal of this study was to evaluate whether the presence of EGFR (Epidermal Growth Factor Receptor) mutations in patients with NSCLC treated by radiochemotherapy, would have an impact on the disease prognosis and survival. Materials and methods: This was a historical/retrospective cohort study using data and history from patients treated at Regiomed Klinikum Coburg between 2016 and 2020, based on specific and predefined inclusion and exclusion criteria. Out of 432 patients...

: Retrospective comparison of thyroid hormone levels in patients following a SARS-CoV-2 (COVID-19) infection; Hanna Heitmann
Objectives: The objective of this study was to collect regional data of Upper Franconia and observe the association between thyroid parameters thyroid-stimulating-hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4) and an infection with SARS- CoV- 2. It was set to investigate the prevalence of patients with abnormal thyroid parameters (outside the range of reference), the association of COVID-19 infection on thyroid gland secretion based on laboratory parameters of routine...

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