Objective: The goal of this research was to determine frequency of infections caused by Campylobacter bacteria in outpatients in Split-Dalmatia county in 2021., their distribution according to age, gender, place of residence and months of the year as well as to determine the antimicrobal susceptibility of Campylobacter spp. isolates. Materials and methods: The data used in this research were taken from the computer data base of the Department for gastrointestinal tract infections diagnosing of the TIPH SDC Split, and they included all of the patients who were diagnosed with Campylobacter spp. bacteria in their stool samples during the period from the 1st of January 2021. to the 31st of December 2021. The data were analyzed using the Microsoft Office 365 software package, and programs Social Science Statistics and VassarStats for statistical analysis. Results: The total number of Campylobacter spp. isolates from stool samples in the area of Split-Dalmatia County in 2021. was 395. The most common isolate was Campylobacter jejuni (92,4%). Infections were significantly more frequent in men than women. The highest number of infections was present in the age groups 0-4 and 20-29 years. Also, the number of patients in urban areas was significantly higher than in suburban and rural areas. The highest number of infections was detected during the period from March through October with a peak in May. In comparison with other previous research that took place in Split-Dalmatia County, there has been detected an increase in the number of resistant Campylobacter jejuni isolates to ciprofloxacin and tetracycline, while the percentage of TcR/CipR co-resistant isolates remained stable. 5,3% of Campylobacter jejuni isolates also showed resistance to amoxicilin-clavulanate. All of the Campylobacter jejuni strains resistant to amoxicilin-clavulanate were also multiple resistant to other two or more antibiotics. Out of the 5 Campylobacter coli isolates included in the research, all five were resistant to ceftriaxone and cefazolin, 3 of them were resistant to ciprofloxacin, and 2 strains demonstrated resistance to tetracycline. Campylobacter coli showed good susceptibility to tested antibiotics. Camyplobacter lari isolate was resistant to ciprofloxacin, ceftriaxone and cefazolin, and was susceptible to other tested antibiotics. Two of the Campylobacter coli isolates were TcR/CipR co-resistant, while others did not show double or multiple resistance. Conclusion: The epidemiological characteristics of campilobacteriosis in outpatients in 2021. were similar to the characteristics determined in SDC in previous research in this area, in fact this pattern is similar to patterns of campylobacteriosis in other developed countries. There has been shown an increase in resistance to ciprofloxacin and tetracycline of Campylobacter jejuni isolates. Also, there has been confirmed the presence of multiple resistant Campylobacter jejuni isolates, while the resistance of these isolates to amoxicilin-clavulanate and erythromicin was low. There was also noted the higher resistance of Campylobacter coli isolates to ceftriaxon and ciprofloxacin, as well as moderate resistance to tetracycline. Considering these in vitro antimicrobial susceptibility results of Campylobacter isolates, erythromycin still remains the drug of choice, but it is also possible to treat this infection with amoxicilin- clavulanate because of its low resistance rate.