Objectives: The objective of this study was to collect new data on the post-COVID period, with a specific focus on headaches, including their symptom prevalence, duration, and influencing factors, while comparing different virus variants. the analysis aimed to explore potential associations between its variables, particularly paying attention to smoking/alcohol consumption, gender, age, preexisting headache, immune status, and other Long-COVID symptoms. The study was conducted under the hypothesis that the prevalence and duration of headaches as a post-COVID-19 symptom vary between different variants of SARS-CoV-2. Material and Methods: The study was designed as a retrospective cross-sectional survey conducted in the rural region of Coburg, Bavaria, Germany, including the REGIOMED Hospital. Data was collected from anonymized sources and categorized into four groups based on different phases of the COVID-19 pandemic, including the SARS-CoV-2 wild type, alpha, delta, and Omicron variants. From a total of 1025 former SARS-CoV-2 hospitalized patients, administered from March 2020 to March 2022, 147 participated in the study through an online questionnaire from September to December 2022. The survey data was combined with information obtained from the hospital's information system, Orbis. The survey collected various variables related to Long-Covid, with a specific focus on headache and headacherelated factors, such as gender, smoking/alcohol consumption, immune status, pre-existing health conditions, and Long-Covid symptoms. Statistical analysis was performed using Stata 16 Statistics, including descriptive statistics, the Mann-Whitney U test, the chi-squared test, and Fisher's exact test. The significance level (p-value) was set at <0.05 to assess the significance of the results. Results: The study presented no significant difference in gender distribution across the different phases, as well as no significant association between gender and the occurrence of headaches. However, age was found to be associated with survey response, with respondents tending to be slightly younger compared to non-respondents. With a headache occurrence of 23.81%, there was no significant association between headache prevalence and the different phases of the study. The duration of headaches varied, with individuals experiencing headache for less than 4 weeks (8.8%), 4 to 12 weeks (4.8%), and longer than 12 weeks (10.2%). Nevertheless, no significant association between headache duration and the different phases was found. Headache was found to be significantly associated with tiredness and fatigue, indicating that individuals with headache were more likely to also report feeling tired or fatigued. 63 The study also examined the relationship between preexisting headache and Long-Covid headache, presenting a significant relation. Participants with preexisting headache were more likely to experience headache as Long-Covid symptom. Anosmia, fatigue, and tiredness also were significantly associated with headache, characterized by an increased likelihood of individuals presenting with headaches simultaneously experiencing one or more of those symptoms. No significant associations were found between headache and smoking/alcohol consumption or headache and the participant´s immune status. Conclusion: The study suggests headache as a common symptom among former SARS-CoV2 hospitalized patients, being associated with tiredness, fatigue, preexisting headache, and anosmia. However, the hypothesis that headache presents differently in terms of prevalence and duration across the different phases/variants of SARS-CoV-2 has been proven false. Instead, Long-Covid headache appears to be more influenced by simultaneous occurrences of other Long-Covid manifestations and individual patient factors. The study highlights the importance of considering the interconnectedness of symptoms, comorbidities, and influencing factors in understanding and managing Long-Covid. Nevertheless, further research is needed to explore the underlying mechanisms and potential management strategies for Long-Covid, especially regarding headache.