Objectives: This research seeks to determine the value of MIPO technique in comparison with intramedullary nailing as a method of treatment for diaphyseal tibial fractures, to confirm results that can be found in literature, such as time of radiation and duration of surgery and to add new parameters for comparison, such as infections and other intraoperative and postoperative complications and healing time. Materials and methods: Subjects were patients aged from 25 - 40 years old with tibial diaphyseal fractures treated at the Department of orthopedics and traumatology, University Hospital of Split, Croatia from January 1st, 2007 until December 31st, 2016. Research was conducted by retrospective cross-section analysis of medical records of the patients treated at the Department of orthopedics and traumatology, University Hospital of Split, Croatia. Results: Total of 80 patients were included in this research, of which 40 were treated by MIPO technique and 40 by intramedullary nailing. Neither group had any infections or other intraoperative or postoperative complications. Radiation time was significantly (p<0,001) shorter with MIPO technique (39,48 s) in comparison with intramedullary nailing (85 s). Duration of surgical procedure was also significantly (p<0,001) shorter with MIPO technique (79,53 min) than with intramedullary nailing (110,18 min). Healing time was significantly (p<0,001) shorter with intramedullary nailing (16 weeks) compared with MIPO technique (18 weeks). Conclusions: Advantages of MIPO technique compared with intramedullary nailing are in statistically shorter time of radiation and duration of surgery. Advantage of intramedullary fixation is significantly shorter time of healing than MIPO technique. Regarding infections and other intraoperative and postoperative complications there was no difference between two groups. Further research is required on this subject on bigger groups of patients with further advances in both operative techniques.