Prognostic value of clinical and histopathological characteristics of uveal melanomas. Uveal melanoma is the most common primary intraocular malignant tumor. The aim of this study was to examine the incidence, along with some epidemiological characteristics of uveal melanoma in Split – Dalmatia County in the period of 1991. to 2010. A statistical analysis was also performed to examine the correlation between tumor parameters (localization, size, histopathologic type) and the 5-year survival rate. Data of 50 patients was collected from the archives of the University Department of Ophthalmology, Split University Hospital. Death certificates were collected from the Split Population Registry, Split – Dalmatia County government. Histopathologic confirmation was obtained from the Hospital Department of Pathology, Forensic Medicine and Cytology, Split University Hospital. Population number was collected from the Census 2011. The incidence of uveal melanoma in Split – Dalmatia County in the period of 1991. to 2010. was 0.55 per 100 000. Average age was 64.24 years, with slightly more males (54% versus 46%). The most common tumor localization was the choroid (88%), followed by the ciliary body (8%), and lastly the iris (4%). Right eye was more commonly afflicted (56% versus 44%). Median tumor diameter was 12.8 mm. 5-year survival rate was 42.9%. There was no statistically significant difference in survival rate between groups with different tumor localization. There was also no statistically significant correlation between survival rate and different tumor localizations. There was a statistically significant difference in 5-year survival between different histopathologic types. The group with the mixed type melanoma had the highest mortality rate (χ²=10.720; DF=3; P=0.0133). In conclusion, none of the examined parameters (localization, size and histopathologic type) are by themselves a valid prognostic factor for uveal melanoma survival. Also, the Callender classification seems inadequate when used by itself, so a more definitive morphometric analysis is required for a better diagnosis and prognosis of the disease. Because of the relatively high tumor size median, it is my opinion that routine ophthalmological examinations should be more frequent, especially among the older population who are at a higher risk of developing uveal melanoma.