Objectives: To examine the role of hemodynamic changes found in the ophthalmic artery in patients with vitiligo and their prognostic significance for the development of primary open-angle glaucoma. Materials and methods: During the two-year period from March 2008 to March 2010, 42 patients with vitiligo were examined from the dermatology clinic of the Clinic for Skin and Venereal Diseases. Due to the suspicion of the development of glaucoma, they were referred to the glaucoma clinic at the Clinic for Eye Diseases. For the purpose of detection or control of primary open-angle glaucoma, all subjects underwent a complete ophthalmological examination, which measured visual acuity and intraocular pressure, examined the fundus of the eye, performed biomicroscopy of the anterior segment of the eye with gonioscopy and examined the visual field. Then, all subjects underwent ultrasound of the ophthalmic artery of both eyes at the Clinic for Internal Medicine of the University Hospital Center Split. Results: Of the 42 patients with vitiligo who were examined at the Clinic for Ophthalmology of the University Hospital Center Split due to suspicion of primary glaucoma, glaucoma was diagnosed in 24 (57%) patients. No statistically significant difference was found between the group of patients with glaucoma and the group without glaucoma, either by sex (P=0.307) or by age (P=0.178). In the group of patients with glaucoma, the median duration of vitiligo was 2.83 times longer (P=0.001). The division of patients according to the duration of vitiligo (<= 12.5 years and> 12.5 years) revealed that there were three times more patients with a duration of vitiligo> 12.5 years in the group of patients with glaucoma than without glaucoma (χ2 = 12.8; P=0.001). Statistical analysis of the ophthalmic artery ultrasound findings of both eyes found that there was no significant difference in resistance index, pulsatility index, peak systole flow, and end-diastole blood flow between the group of patients with vitiligo who developed glaucoma and the group of patients who didn't develop glaucoma. Conclusions: Patients with vitiligo with a longer duration of the disease have an increased risk of developing primary open-angle glaucoma. A detailed examination of the ultrasound parameters of the ophthalmic artery of both eyes ruled out the vascular component as a possible cause of glaucoma in patients with vitiligo.