Završni radovi | Repozitorij MEFST

: Early life trauma in war veterans with PTSD and Complex PTSD; Marijeta Ivandić
Objectives: The main objective of this research was to investigate the relationship between early childhood trauma, PTSD, and complex PTSD in war veterans. Materials and methods: Research participants were 88 male war veterans, 40 diagnosed with PTSD and 48 diagnosed with CPTSD. This research was conducted at the Department of Psychiatry, University Hospital Split, and the Regional Center for Psychotrauma. The measurement instruments were four questionnaires: the Clinician-Administered...

: Early preloading with P2Y12 inhibitors in patients presenting with acute coronary syndromes without persistent ST-segment elevation; Bjornar Marcelius
Objectives: The aims of this study were to investigate the impact of early P2Y12 inhibitor preloading (pretreatment) vs. no preloading on short-term clinical outcomes in patients with acute coronary syndromes without persistent ST-segment elevation (NSTE-ACS). Patients and methods: Meta-analysis and quantitative synthesis were performed by including five randomized controlled trials (RCTs) that examined P2Y12 preloading in NSTE-ACS patients. Primary outcomes of interest were composite...

: Efekt liječenja metforminom na odrednice metaboličkog sindroma u djece; Manuela Gregov
Cilj istraživanja: Utvrditi efekte jednogodišnje terapije metforminom u djece sa sumnjom ili potvrđenom dijagnozom MS, na tjelesnu masu, razine glukoze i inzulina natašte i tijekom opterećenja glukozom u OGTT te na razine triglicerida i HDL kolesterola. Materijali i metode: Istraživanje je provedeno na uzorku od 41 ispitanika prosječne dobi 13 ± 2.63 godine. Glavni kriterij uključenja u istraživanje bilo je korištenje metformina kao terapije te sumnja na MS ili potvrđena...

: Effects of the COVID-19 pandemic on suicide attempts in a rural region in Germany : a 5-year observational study; Jule Jannick Arand
Background: People's mental health was negatively affected by the restrictions on public life during the COVID-19 pandemic. Systematic research on the short- and long-term consequences of the COVID-19 pandemic on suicidal behavior is fundamental for developing suicide-preventive measures adapted to the current situation. Methods: Between January 1, 2017, and December 31, 2021, we included patient records that met the DMS-5 criteria for suicidal behavior disorders (n = 825) admitted to a...

: Effects of treatment with sucrose in drinking water on the expression of vitamin D receptors and metabolizing enzymes in the liver of rats; Maximilian Grobe
Objectives: The purpose of this study was to investigate the expression of vitamin D receptors (VDR), CYP24 and 1α hydroxylase (1α OHase) in livers of rats after long-term high sucrose intake. Materials and methods: Eight Wistar rats were divided into two groups. One group receiving water (control group, ctrl.) and the other receiving 30% w/v sucrose solution (sucrose group, sah) as drinking solution ad libitum. All rats were fed with standard laboratory chow (4RF21 GLP, Mucedola srl,...

: Ekspresija CD44 biljega na CD14+CD16++ subpopulaciji monocita u bolesnika s ulceroznim kolitisom; Antonia Alfirević
Cilj istraživanja: Cilj je istraživanja usporedba upalnog odgovora kod različito liječenih pacijenata oboljelih od ulceroznog kolitisa. Materijali i metode: Uzorci krvi svih sudionika uzeti su za analizu. Uzorak je tretiran Fc-receptor blokirajućim reagensom te je uzorak inkubiran 20 minuta bez izvora svjetlosti pri sobnoj temperaturi uz dodatak anti-humanog CD14s PerCP-Cy5.5-konjugiranog protutijela i protutijela konjugiranog fikoeritrinom, reaktivnog na humani CD16 te dodatak...

: Ekspresija p53 proteina u trostruko negativnim karcinomima dojke; Ivan Abaza
Cilj istraživanja. Trostruko negativni tumori dojke su grupa tumora karakterizirana negativnim statusom HER2-neu receptora i receptora za steroidne hormone, a čine 10 do 20% karcinoma dojke. Spadaju u skupinu tumora s lošijom prognozom zbog agresivnog ponašanja i nedostatka ciljane terapije. Cilj ovog istraživanja bio je utvrditi razinu ekspresije p53 proteina u trostruko negativnim karcinomima dojke, te njegovu povezanost s kliničkopatološkim prognostičkim pokazateljima,...

$Elastic stable intramedullary nail fixation for displaced fractures of the neck of the radius in children in the Department of pediatric surgery, University hospital of Split between 2011 - 2017 : a retrospective study$: Elastic stable intramedullary nail fixation for displaced fractures of the neck of the radius in children in the Department of pediatric surgery, University hospital of Split between 2011 - 2017 : a retrospective study; Andre Nikolai Capitain
Objective: The aim of the study was to establish the demographic and clinical characteristics of children operated by the ESIN method for radial head and neck fractures, analyze the outcomes of treatment and the rate of complications, and compare them with other relevant studies. Subjects and Methods: From May 2011 to May 2017, 26 children treated with the ESIN method for radial head and neck fracture, in the Department of pediatric surgery of the University hospital of Split, were...

: Elektivni ponovljeni carski rez u KBC-u Split; Sara Cokarić
Ciljevi: Istražiti modalitet dovršenja trudnoće i/ili porođaja nakon prethodnog carskog reza te utvrditi povezanost biranog načina s obilježjima majki (paritet, gestacijski dijabetes, preeklampsija), novorođenčadi (spol, tjelesna masa i duljina, makrosomija, APGAR ocjena vitalnosti, vrijednost pH krvi iz pupkovine) i trudnoća (dob trudnoće u trenutku porođaja, jednoplodove, višeplodove). Analizirati indikacije elektivnog ponovljenog carskog reza, sudjelovanje pojedinih liječnika...

: Elektrokemijska stabilnost titanizirane kirurške mrežice u fiziološloj otopini; Toma Ujević
Cilj: Cilj ovoga istraživanja je dokazati elektrokemijsku stabilnost titanizirane kirurške mrežice u fiziološkoj otopini te dokazivanje stabilnosti pri promjeni fizoloških uvjeta. Metode: U ovom radu je mjerenjem potencijala otvorenog strujnog kruga te primjenom impedancijske spektroskopije ispitana elektrokemijska stabilnost medicinske titanizirane mrežice u standardnoj fiziološkoj otopini (pH 6.5) te fiziološkoj otopini snižene pH vrijednosti (pH 5.5). Rezultati: Dobiveni...

: Endokrinološke komplikacije anoreksije nervoze u djece i adolescenata; Lea Toula
CILJ ISTRAŽIVANJA: Pokazati učestalost i obilježja netiroidne bolesti štitnjače u djece i adolescenata s restriktivnim tipom anoreksije nervoze. MATERIJALI I METODE: U ovo retrospektivno istraživanje bilo je uključeno 105 pacijentica u dobi od 11 do 20 godina, od kojih je 96 bilo hospitalizirano na Odjelu za gastroenterologiju Klinike za pedijatriju KBC-a ˶Sestre milosrdnice˝ u Zagrebu i 19 na Odjelu za gastroenterologiju Klinike za pedijatriju KBC-a Split pod dijagnozom AN u...

: Endovascular mechanical thrombectomy for the treatment of stroke in University Hospital of Split : our experience; Pezhman Rasouli
Objectives: To evaluate the effectiveness of endovascular mechanical thrombectomy in acute ischemic stroke patients. Time dependency of whole process and correlation of different intervention related time factors with the mRS outcomes after 3 months were investigated as well. Subjects and Methods: A sample of 48 patients was chosen from University Hospital Split over a time span of 1 year (from January 2020 till end of December 2020) based on specific and predefined inclusion and...

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