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Expression pattern of Snail in the kidneys of streptozotocin-induced diabetic rats
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Samy Mehdi Ksouri Objectives: The most prevalent cause of chronic kidney disease is diabetic nephropathy (DN), which can lead to end-stage renal disease (ESRD) and premature death in developed countries but knowledge about these changes is still unsatisfactorily. Specific factors can be used to study developmental pathways and changes in rat diabetic kidneys. Snail is a superfamily of genes that has been found to control gastrulation and neural crest EMT through E-cadherin down-regulation. Snail is located in...
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Expression pattern of Syndecan-1 and HSP-70 in hip tissue of patients with osteoarthritis
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Julian Kaufman Objectives: The purpose of this study is to investigate the expression of Syndecan-1 and HSP-70 in synovial, chondral and subchondral tissue in the hip of human patients with osteoarthritis according to their disease severity.
Materials and methods: Total hip arthroplasty with tissue extraction from the weightbearing area of the pathologic femoral head was performed on all patients. Patients were divided into two groups according to their disease severity defined by their Kellgran Lawrence,...
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Expression pattern of apoptosis-inducing factor in the kidneys of streptozotocin-induced diabetic rats
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Tim Julian Hauke Objectives: The aim of this study is to investigate the significance of AIF expression in the development of DKD by observing the expression of AIF in 2 weeks and 2 months diabetic kidney samples and then comparing them to healthy rat kidneys of the same age.
Materials and methods: Diabetes mellitus (DM) was induced by i/p injecting 55 mg/kg streptozotocin (STZ) to male Sprague-Dawley rats, and was validated by measuring blood glucose level. Control group received citrate buffer. Animals...
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Extended molecular testing of consecutive tumor specimen and subsequent treatment
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Finja Marie Schwenkenbecher Objectives: The purpose of this study is to confirm, whether detailed genetic testing of
patients with advanced tumor stage provides the basis for new molecular targeted therapies
and to determine, if detailed genetic testing extends treatment options and improves the
outcome. In addition, the frequency of molecular alterations and their level of evidence were
determined in an unselected group of patients. Furthermore, we investigated the frequency of
targetable genomic aberrations and...
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Farmakoekonomske analize ljekarničkih usluga
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Ana Božinović - Karauz Cilj istraživanja: Cilj ovog diplomskog rada je osvrt na izdvojene recenzirane studije koje donose rezultate o učinkovitosti, uspješnosti i isplativosti provedenih farmakoekonomskih analiza ljekarničkih usluga. Kontekst ovog istraživanja su ljekarničke usluge u Hrvatskoj koje još uvijek nisu vrednovane, ali postoji potreba da se troškovi pružanja ljekarničkih usluga kvantificiraju.
Ispitanici i metode: Za izradu ovog diplomskog rada pretraživanje literature je provedeno od 1....
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Farmakoterapija bolesnika sa šećernom bolesti hospitaliziranih zbog SARS-CoV-2 infekcije
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Ivana Šumera Cilj istraživanja: Cilj ovog istraživanja bio je usporediti farmakoterapiju bolesnika sa šećernom bolesti pri prijemu u bolnicu zbog bolesti COVID-19, u odnosu na farmakoterapiju bolesnika sa šećernom bolesti pri otpustu iz bolnice.
Materijali i metode: U svrhu istraživanja prikupljeni su podatci 40 bolesnika sa šećernom bolesti hospitaliziranih u KBC-u Split zbog infekcije SARS-CoV-2 u periodu od listopada do prosinca 2021. godine. Kriterij uključenja ispitanika u istraživanje...
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Farmakoterapijski pristup liječenju depresija u Klinici za psihijatriju KBC Split
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Andrea Grga Cilj istraživanja:
Utvrditi najučinkovitiji način liječenja depresije u odnosu na težinu kliničke slike prema tri
ocjenske ljestvice za depresiju (Hamiltonova ocjenska ljestvica depresije, Montgomery–
Asbergova ocjenska ljestvica depresije, Opći klinički dojam), te vremenski period za
uspostavljanje psihološkog, socijalnog i radnog funkcioniranja u bolesnika oboljelih od
depresije u trajanju od 6 mjeseci.
Ustroj istraživanja:
Istraživanje je provedeno na uzorku od 40...
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Fas Ligand expression on Extravillous Trophoblast in placentas from pregnancies complicated with HELLP syndrome
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Marie Kurtz Objectives: to compare the staining for Fas Ligand receptor on EVTB in placentas with and without HELLP syndrome. Maternal and gestational age, as well as parity, fetal weight and IUGR were also investigated and analyzed for differences.
Subject and method: 10 placentae with HELLP syndrome and 10 control placentae were enrolled in the study. Both groups were immunohistochemically stained with antibody to FasL. We used the HSCORE method for assessment of the immunohistochemical staining of...
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Fazni kut : prediktor rizika u kolorektalnoj kirurgiji
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Marija Rafaela Plosnić Cilj istraživanja: Cilj ovoga istraživanja bio je utvrditi povezanost faznoga kuta u različitim vremenskim intervalima kao rizičnoga faktora za razvoj komplikacija, povećanja broja rehospitalizacija, reoperacija i smrti te ga povezati sa stadijem bolesti, PHD nalazom i dijagnozom. Fazni kut je i promatran kao prediktor malnutricije, te je istražena njegova korelacija s parametrima dobivenih biometrijskom analizom sastava tijela.
Materijal i metode: U svrhu dobivanja podataka o broju...
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Fazni kut kao prediktor ranih poslijeoperacijskih komplikacija u bolesnika elektivno operiranih zbog kolorektalnog karcinoma
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Ana Stipić Cilj: Cilj ovog istraživanja je ispitati povezanost faznog kuta i pojave ranih poslijeoperacijskih komplikacija u bolesnika koji su elektivno operirani zbog kolorektalnog karcinoma.
Ispitanici i metode: Provedeno je retrospektivno istraživanje koje je uključivalo 88 bolesnika elektivno operiranih zbog kolorektalnog karcinoma. Liječeni su u skladu s protokolom ubrzanog oporavka nakon kirurškog zahvata (ERAS) u Klinici za kirurgiju Kliničkog bolničkog centra Split u razdoblju od 1....
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