Završni radovi | MEFST Repository

: Immunohistochemical expression of podoplanin in renal cell carcinomas; Hannes Stoll
Objectives: The aim was to assess the immunohistochemical expression of PDPN/D2-40 in the three most common types of renal cell carcinoma, clear cell renal cell carcinoma (CCRCC), papillary renal cell carcinoma (PRCC) and chromophobe renal cell carcinoma (ChRCC). Additionally, we wanted to determine if there is a correlation between cancer aggressivity and metastatic potential and an increase of PDPN expression in aforementioned tumors. Materials and methods: Our study included 15...

: Impact of atrial fibrillation on outcomes in patients undergoing transcatheter mitral valve repair; Johann Jakob Friedrich Strohmaier
Objective: The aim of this study was to examine the impact of AF in patients with severe MR after being treated by PMVR. Material and Methods: All patients who underwent PMVR with MitraClip for severe mitral regurgitation and were enrolled between 2016 and 2021 during a 5-year period were included in the registry study. Two groups of patients were created: one with AF (group A) and the other without (group B). Following this, there was a comparison of the two groups' clinical...

: Impact of interventional cardiology under the influence of COVID-19; Franziska Leandra Kiefer
Background: With mitral regurgitation being the most common valve disease in the industrialized world, it affects roughly 10% of elderly over the age of 75 years. Due to demographic changes, its prevalence is thought to even increase in the future. TEER, particularly the MitraClip® system, is a suitable option for patients with an increased surgical risk. This thesis addresses the question of how the strained healthcare system during the pandemic has affected cardiological patients...

: Impact of left atrial fibrosis tissue before and induced scar tissue after pulmonary vein isolation on left atrial function detected using cardiac-MRI in patients with atrial fibrillation; Mariella Franziska Andrea Zuber
Objectives: The aim of this study is to determine the influence of atrial fibrosis before and induced scar tissue after PVI on the left atrial function in patients with paroxysmal AF. Materials and methods: 30 patients from the cardiology department of REGIOMED Hospital in Coburg, Germany, were included in this retrospective, non-invasive and non-randomized study, using data collected between June 2021 and June 2022. Inclusion criteria comprised high-quality MRI scans, sinus rhythm during...

: Impact of the COVID-19 pandemic on the time-to-picture and the picture-to-puncture time in acute stroke patients in a rural region: a restropsective cohort study; Lavinia Jürgens
Objectives: Acute ischemic stroke (AIS) is a frequently encountered and severe medical emergency needing rapid intervention. This thesis aimed to investigate whether the COVID-19 pandemic has resulted in an increase in the duration of the workflow associated with Mechanical Thrombectomy (MT) treatment for patients with acute ischemic stroke. Material and methods: This retrospective cohort study analyzed 218 subjects who MT at REGIOMED hospitals in Coburg, Sonneberg, and Lichtenfels, both...

: Impella hemodynamic support for cardiogenic shock and high-risk percutaneous coronary intervention: Initial experiences at the University Hospital of Split; Raffael Ivo Ferdinand Avelini
Objectives: This study sought to describe the initial experiences, clinical features, safety, and effectiveness of Impella CP® hemodynamic support for cardiogenic shock (CS) and high risk percutaneous coronary intervention (HR-PCI). Specific goals were to evaluate baseline characteristics, comorbidities, laboratory markers, echocardiographic findings, complications, in-hospital, and procedure-related mortality. Materials and methods: This retrospective study was conducted at the Clinic...

: Imunofenotipizacija u bolesnika s multiplom sklerozom liječenih okrelizumabom u KBC-u Split; Marija Radmilo
Cilj istraživanja: Prikazivanje i usporedba imunofenotipizacije T-limfocita, B-limfocita i NK stanica prije primjene prve i prije primjene druge doze okrelizumaba u bolesnika oboljelih od MS-e u KBC-u Split od 1. siječnja 2019. do 31. prosinca 2021. godine. Ispitanici i postupci: Uključeno je 22 pacijenata oboljelih od MS-e starijih od 18 godina koji su se liječili okrelizumabom u Klinici za neurologiju KBC-a Split u navedenom trogodišnjem razdoblju. Analizirani su podatci o spolu,...

: Imunohistokemijska analiza HER2 statusa u karcinomu debelog crijeva – četverogodišnja retrospektivna studija; Lucija Bonković
Ciljevi: Osnovni ciljevi ovog istraživanja bili su utvrditi razinu izražaja HER2 receptora u kolorektalnim karcinomima te utvrditi povezanost izražaja HER2 receptora sa kliničko-patološkim karakteristikama tumora. Materijali i metode: U istraživanje je uključeno 144 bolesnika s kolorektalnim karcinomom za koje je u razdoblju od 1. siječnja 2019. godine do 31. prosinca 2022. godine na Kliničkom zavodu za patologiju, sudsku medicinu i citologiju KBC-a Split imunohistokemijski...

: Imunohistokemijska analiza liganda programirane stanične smrti 1 u trostruko negativnim karcinomima dojke – četverogodišnja retrospektivna studija; Kristian Marinović
Ciljevi istraživanja: Glavni su ciljevi istraživanja bili su odrediti udio trostruko negativnih karcinoma dojke s pozitivnim PD-L1 statusom, korelirati PD-L1 status s ostalim ispitivanim kliničko-patološkim karakteristikama tumora te utvrditi postojanje promjene PD-L1 statusa u različitim vrstama patohistoloških uzoraka. Ispitanici i postupci: U istraživanje je uključeno 112 ispitanika, kojima je na Zavodu za patologiju, sudsku medicinu i citologiju, KBC-a Split u razdoblju od...

: Imunohistokemijski izražaj E-kadherina u trostruko negativnim karcinomima dojke; Ornella Bogdan
Cilj istraživanja. Karcinom dojke najčešći je maligni tumor u žena i važan javnozdravstveni problem diljem svijeta. Trostruko negativni karcinomi (TNBC) čine 10 do 20 % svih karcinoma dojke, karakterizirani su negativnim statusom receptora za steroidne hormone i HER-2-neu receptor, a povezuju se s agresivnijim kliničkim tijekom. Cilj ovog istraživanja bio je utvrditi imunohistokemijski izražaj E-kadherina u trostruko negativnim karcinomima dojke, te njegovu povezanost s...

: Imunohistokemijski izražaj GLUT1 u karcinomima bubrega; Marin Ogorevc
Ciljevi istraživanja: usporediti imunohistokemijski izražaj GLUT1 prijenosnika između skupina svijetlostaničnog, papilarnog i kromofobnog karcinoma bubrega. Također, usporediti ćemo izražaj GLUT1 prijenosnika između skupina karcinoma bubrega različitog nuklearnog gradusa. Materijal i metode: U studiju je uključeno osam uzoraka svijetlostaničnog, sedam uzoraka papilarnog i četiri uzorka kromofobnog karcinoma bubrega. Svi uzorci su imunohistokemijski obojeni s protutijelom na...

: Imunohistokemijski izražaj HIF-1α u inicijalno metastatskim i inicijalno nemetastatskim tumorima testisa; Tea Livaja
Cilj istraživanja: Tumori testisa su relativno rijetki te čine tek 1-2% svih malignih tumora kod muškaraca. Unatoč tome, oni su najčešći maligni tumori muškaraca između 15 i 35 godina. Jednim od glavnih okolišnih čimbenika u patogenezi tumora testisa smatra se hipoksija, koja dovodi do aktivacije transkripcijskog faktora HIF-1α. U brojnim studijama uočena je korelacija HIF-1α i rezistencije na radio/kemoterapiju te metastatskog potencijala tumora. Prema tome, glavni cilj ovog...

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